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Figure 3. Plasmon-waveguide resonance PWR determines both binding kinetics and conformational changes. A polarized continuous wave laser excites electromagnetic waves in a resonator made of a thin silver film with a layer of SiO2 and a glass prism.


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The resonance angle shifts when drug compounds bind to the immobilized target. Figure 4. Microplate-based resonant waveguide grating RWG determines binding affinity screening. Light is coupled into the waveguide via diffraction.

The intensity of the reflected light is measured. The compound binding of the immobilized receptors causes a shift in the resonant wavelength. Figure 5. Biolayer interferometry biosensor BIB.

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A broadband light resource is used to illuminate the interfaces. Reflected light waves originate from the immobilized receptor surface and the optical layer, interacting with each other and creating interference patterns.


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Compound binding affects the inference pattern. Figure 6. The magnetization transfer between two protons is represented by arrows. Nuclear Overhasuer effects NOEs are represented by black dots and white dots represent intermolecular NOEs are represented by white dots. Pharmacol Rev. Fang Y. Ligand-receptor interaction platforms and their applications for drug discovery.

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NMR-based analysis of protein-ligand interactions. Anal Bioanal Chem. Owicki J. Fluorescence polarization and anisotropy in high throughput screening: perspectives and primer. J Biomol Screen. Methods Mol Biol. Ligand-receptor kinetics measured by total internal reflection with fluorescence correlation spectroscopy. Biophys J. Handl H, Gillies R. Lanthanide-based luminescent assays for ligand-receptor interactions.

Life Sci. Rossi A, Taylor C. Analysis of protein-ligand interactions by fluorescence polarization. Nat Protoc. J Vis Exp. Labaer J, Ramachandran N. Protein microarrays as tools for functional proteomics. Curr Opin Chem Biol. Screening kinase inhibitors with a microarray-based fluorescent and resonance light scattering assay.

Anal Chem. Fluorescence- and bioluminescence-based approaches to study GPCR ligand binding. Br J Pharmacol.

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Charest Morin X, Marceau F. Eur J Med Chem.


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J Med Chem. Selective nonpeptidic fluorescent ligands for oxytocin receptor: design, synthesis, and application to time-resolved FRET binding assay. Nanofluidic Fluorescence Microscopy NFM for real-time monitoring of protein binding kinetics and affinity studies. Biosens Bioelectron.

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Development of a quantitative fluorescence-based ligand-binding assay. Sci Rep. Scintillation proximity assays in high-throughput screening. Assay Drug Dev Technol. Hulme E, Trevethick M. Ligand binding assays at equilibrium: validation and interpretation. Radioligand saturation binding for quantitative analysis of ligand-receptor interactions. Biophys Rep. Catani V, Gasperi V.

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Assay of CB1 Receptor Binding. Flanagan C. GPCR-radioligand binding assays. Methods Cell Biol. Characterization of monoacylglycerol acyltransferase 2 inhibitors by a novel probe in binding assays. Anal Biochem. Curr Protoc Pharmacol. Chu U, Ruoho A. Sigma Receptor Binding Assays. Use of radiolabeled antagonist assays for assessing agonism at D2 and D3 dopamine receptors: comparison with functional GTP? S assays. J Neurosci Methods.

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Target engagement and drug residence time can be observed in living cells with BRET. Nat Commun. Visualizing real-time influenza virus infection, transmission and protection in ferrets. Quantitative measurement of cell membrane receptor internalization by the nanoluciferase reporter: Using the G protein-coupled receptor RXFP3 as a model. Biochim Biophys Acta.

Application of the novel bioluminescent ligand-receptor binding assay to relaxin-RXFP1 system for interaction studies. Amino Acids. Novel bioluminescent receptor-binding assays for peptide hormones: using ghrelin as a model. Quick preparation of nanoluciferase-based tracers for novel bioluminescent receptor-binding assays of protein hormones: Using erythropoietin as a model. J Photochem Photobiol B. Daghestani H, Day B. Theory and applications of surface plasmon resonance, resonant mirror, resonant waveguide grating, and dual polarization interferometry biosensors. Sensors Basel.

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